Modern Healthspan

• The Alzheimer's Scientist: This $1.50 Supplement Reversed Memory Loss In 8 Weeks | Matthew Taylor

  Could a simple supplement that bodybuilders use to build muscle actually help fight Alzheimer's disease? Dr. Matthew Taylor from the University of Kansas reveals surprising results from her groundbreaking clinical trial testing high-dose creatine in Alzheimer's patientsIn this episode, Dr. Matthew Taylor discusses his pioneering research on creatine supplementation for Alzheimer's disease, addressing a critical gap in brain energy metabolism that worsens with aging and becomes severely impaired in dementia. His 8-week clinical trial gave 20 Alzheimer's patients 20 grams of creatine daily - a bodybuilder's loading dose - and found remarkable improvements in memory, executive function, and even unexpected gains in reading comprehension. Using advanced MRI spectroscopy, his team confirmed that creatine actually reaches the brain, increasing levels by 11%. Beyond cognitive benefits, participants also showed significant improvements in hand grip strength and muscle mass. Dr. Taylor explains how brain energy metabolism creates a vicious cycle in Alzheimer's, explores whether creatine could prevent dementia in healthy aging, and reveals his plans for combining creatine with ketogenic diet approaches. This conversation offers hope for a simple, accessible intervention that could help millions facing cognitive decline.🌐Links in this video Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognitionhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12089086/Dr Taylor's website at Kansas University https://www.kumc.edu/mtaylor3.htmlSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comAll Muse devices 15% discount code MODERN https://choosemuse.com/MODERNStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

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• This Therapy May Cure AIDS And Extend Your Lifespan | Dr Alessio Lanna

  A potential functional cure for HIV could be just months away from human trials. Dr. Lanna reveals how her company Sentcell is using cellular rejuvenation to eliminate HIV reservoirs—and the surprising anti-aging benefits that come with it.n this groundbreaking interview, Dr. Lanna, founder and CEO of Sentcell, explains how his team has developed a revolutionary approach to HIV treatment that could eliminate the need for lifelong antiretroviral therapy. Unlike traditional strategies that target the virus directly, Sentcell's method uses a molecule called DOS to rejuvenate CD4 T-cells, triggering them to naturally clear HIV DNA from their own genomes through a process that mimics elite controllers—rare individuals who can suppress HIV without medication. The treatment works by reactivating dormant cellular pathways that outcompete HIV's integration machinery, effectively reversing viral integration and clearing infected cells within days to weeks. Beyond HIV, Dr. Lanna discusses his team's discovery of "rivers of telomeres"—vesicle structures released by rejuvenated T-cells that can systemically rejuvenate other organs and extend lifespan by 12-17 months in animal studies. With Phase 1 human trials planned for 2026 at University College London, this research represents a potential paradigm shift from managing HIV as a chronic condition to achieving a functional cure.🌐Links in this video Sentcell website https://sentcell.life/ Dr Lanna on LinkedIn https://www.linkedin.com/in/professor-alessio-lanna-ph-d-687a1bb1/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comAll Muse devices 15% discount code MODERN https://choosemuse.com/MODERNStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

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• Groundbreaking New Study Reveals Why Your High LDL May Be Fine | Nick Nowitz, Dave Feldman, Adrian Soto-Mota

  When someone's LDL cholesterol hits 574 mg/dL, doctors typically expect the worst. But what if everything we think we know about cholesterol and heart disease risk is incomplete?In this episode, I sit down with researchers Nick Norwitz, Adrian Soto-Mota, and Dave Feldman to discuss their groundbreaking study on lean mass hyperresponders - a rare population who develop extremely high LDL cholesterol on ketogenic diets despite being lean, fit, and metabolically healthy. Their recent paper "Plaque Begets Plaque, ApoB Does Not" challenges conventional wisdom by showing that in this unique population, neither LDL cholesterol nor ApoB levels predicted plaque progression over one year of follow-up. Instead, existing plaque was the strongest predictor of future plaque growth. We explore the proposed lipid energy model that may explain why some people's cholesterol skyrockets on keto, discuss the limitations and implications of their findings, and examine what this means for personalized cardiovascular risk assessment. This conversation touches on fundamental questions about causality in medicine, the importance of studying outlier populations, and why a one-size-fits-all approach to cholesterol management may be missing crucial nuances.🌐Links in this video Longitudinal Data From the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not https://pubmed.ncbi.nlm.nih.gov/40192608/Citizen Science Foundation https://citizensciencefoundation.org/Nick's home page https://www.nicknorwitz.com/On XNick Nowitz https://x.com/nicknorwitzDave Feldman https://x.com/realDaveFeldmanAdrian Soto-Mota https://x.com/AdrianSotoMotaSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comAll Muse devices 15% discount code MODERN https://choosemuse.com/MODERNStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

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• Senescent Cell Expert: Big Pharma Walked Away, But The Future Is Bright | Dr Paul Robbins

  Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach.Some links are affiliate links so we will earn a commission when they are used to purchase products.In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. Dr. Robbins also shares insights into next-generation compounds his lab is developing and hints at positive clinical trial results coming soon.🌐Links in this video APERS & TRIALSFisetin at the ITPAstaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules usedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10828146/Bone strength trialTargeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humanshttps://clinicaltrials.gov/study/NCT04313634Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (SToMP-AD)https://www.clinicaltrials.gov/study/NCT04685590Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerabilityhttps://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00046-4/fulltextSenolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old agehttps://pmc.ncbi.nlm.nih.gov/articles/PMC9924942/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comAll Muse devices 15% discount code MODERN https://choosemuse.com/MODERNStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

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• The Mitochondria Scientist: This Light Is Silently Aging You Faster | Dr Glen Jeffery

  DESCRIPTIONNeuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.🌐Links in this video Dr Jeffery's page at UCL https://profiles.ucl.ac.uk/7465-glen-jefferyLinks to the NASA Study and write upComprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impacthttps://www.cell.com/cell/fulltext/S0092-8674(20)31461-6https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/Some papers mentioned in the inteviewLonger wavelengths in sunlight pass through the human body and have a systemic impact which improves visionhttps://www.nature.com/articles/s41598-025-09785-3Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expressionhttps://www.nature.com/articles/s41598-025-89081-2Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comAll Muse devices 15% discount code MODERN https://choosemuse.com/MODERNStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

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