Modern Healthspan

Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly.
Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, including why they get the same diseases as the rest of us, just decades later, and what that means for the goal of longevity medicine. We then move into the practical territory: what criteria distinguish a drug that treats one disease from one that may target aging itself, which four currently approved drugs score highest on that framework, and how leading longevity physicians are beginning to use them in practice. We also discuss GLP-1 agonists in depth; their mechanisms, the emerging evidence for benefits well beyond weight loss, and the important caveats around muscle loss. Essential viewing for anyone following the science of healthy aging.

🌐Links in this video
Dr Barzilai at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai Healthy Longevity Medicine Society https://hlms.co/ American Federation for Aging Research https://www.afar.org/ Academy for Health & Lifespan Research https://www.ahlresearch.org/

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GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs.
We go far beyondweight loss. Dr. Kolonin explains how GLP-1 drugs trigger IL-6 signaling in fattissue, activating a thermogenic program that converts metabolically inactivewhite fat into energy-burning brown fat and how in some patients this isaccompanied by upregulation of telomerase, a protein with profound implicationsfor mitochondrial health and aging. We also tackle the muscle loss questiondirectly, examining what the latest research reveals about why lean mass losson GLP-1s exceeds simple caloric restriction, and what can realistically bedone about it.
 
🌐Linksin this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9
 
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Dr. Anurag Singh, Chief Scientific Officer at Timeline Nutrition joins Modern Healthspan for an in-depth conversation about urolithin A and the science of mitophagy, the cellular process that cleans out damaged mitochondria.
We explore the clinical evidence from multiple human trials: the ATLAS trial showing 12% muscle strength gains and 10% VO2 max improvements in sedentary middle-aged adults, independent studies in elite athletes demonstrating enhanced recovery and performance, and the groundbreaking MitoImmune trial published in Nature Aging revealing 20% increases in immune cell mitochondria in just 28 days.
Dr. Singh provides practical guidance on dosing (500mg vs 1000mg), timing, and who benefits most from supplementation. We discuss why only 30% of people can produce urolithin A naturally from foods like pomegranates and berries, and how direct supplementation overcomes this limitation.
Looking ahead, we cover Timeline's Healthspan XPrize semi-finalist status, ongoing blood-brain barrier research setting the stage for brain health trials, and Dr. Singh's vision for combining mitophagy activation with emerging therapies like mitochondrial transplantation. He also shares why he believes mitochondrial dysfunction is "the mother of all hallmarks of aging."
Whether you're interested in the science of healthy aging, considering urolithin A supplementation, or want to understand the future of longevity medicine, this comprehensive conversation provides the evidence and insights you need.
Topics covered:
• What urolithin A is and how mitophagy works
• ATLAS trial results: muscle, endurance, and inflammation
• MitoImmune trial: immune system rejuvenation
• Practical supplementation guide
• Brain health research and future directions
• The role of mitochondrial health in aging

🌐Links in this video
Time-Line home page https://www.timeline.com/ ATLAS Trial: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://pubmed.ncbi.nlm.nih.gov/35584623/ Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial https://www.nature.com/articles/s43587-025-00996-x

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Dr. Valter Longo explains how fasting-mimicking diets make cancer cells vulnerable to treatment while protecting healthy tissue, plus the clinical evidence, safety protocols, and why oncologists remain skeptical.

Dr. Valter Longo, author of "Fasting Cancer," breaks down decades of research on using fasting-mimicking diets (FMD) alongside conventional cancer therapies. Cancer cannot be starved but it can be metabolically weakened by limiting resources which a the same time protects healthy cells. A process known as differential stress resistance. We cover: the mechanism behind why this works, clinical trial results in triple-negative breast cancer and other aggressive cancers, the surprising data on weight loss and cachexia, BMI cutoffs and safety protocols, how to approach your oncologist, prevention versus treatment applications, and the cutting-edge "escape pathway" research that could transform personalized cancer treatment. Dr Longo addresses the elephant in the room: why, despite promising results in both mouse models and human trials, this approach faces massive institutional and regulatory barriers to becoming standard of care. Practical, evidence-based information for patients, caregivers, and anyone interested in the intersection of nutrition and cancer biology.

🌐Links in this video
Create Cures Foundation https://createcures.org/ - Dr Longo organization in the US The Valter Longo Foundation https://www.fondazionevalterlongo.org/en/ - Dr Longo's organization in Italy and rest of the world Dr Longo's website https://valterlongo.com/ Facebook https://www.facebook.com/profvalterlongo/ Instagram https://www.instagram.com/prof_valterlongo/ Fasting Mimicking Diet company Prolon https://prolonlife.com/

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Dr. Luigi Ferrucci reveals what 60 years of Baltimore Longitudinal Study data shows about aging, inflammation, mitochondria, and the biomarkers that predict your health trajectory.In this conversation, Dr. Luigi Ferrucci, Scientific Director of the National Institute on Aging and director of the Baltimore Longitudinal Study of Aging, shares insights from the longest-running scientific study of human aging.We discuss why measuring the pace of aging matters more than a single snapshot, how mitochondrial function drives the entire aging process, and why chronic inflammation may be a secondary response rather than a primary cause of aging. Dr. Ferrucci reveals which biomarkers should be in clinical use right now (including GDF-15), what the BLSA data shows about people who age successfully, and the specific lifestyle factors that add nine years of healthy life expectancy.This is essential viewing for anyone interested in longevity science, biological age testing, and evidence-based interventions to slow aging. Dr. Ferrucci brings decades of rigorous research to questions about what actually works and what we're still learning.🌐Links in this video Dr Ferrucci's page at the NIA https://irp.nih.gov/pi/luigi-ferrucciBaltimore Longitudinal Study of Aging main site https://www.nia.nih.gov/research/labs/blsaThe Baltimore Longitudinal Study of Aging (BLSA): A 50-Year-Long Journey and Plans for the Futurehttps://pmc.ncbi.nlm.nih.gov/articles/PMC5004590/#longevity #healthspan #aging
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