Modern Healthspan

Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.🌐Links in this video Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trialhttps://pubmed.ncbi.nlm.nih.gov/38956196/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.🌐Links in this video Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brennerX (Twitter) https://x.com/CharlesMBrenner/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.🌐Links in this video Dr Meikle's page at Baker https://baker.edu.au/research/staff/peter-meiklePelagic AI https://pelagicai.it/Juvanescence https://juvlabs.comSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Genetics professor Dr. Jan Vijg explains how DNA damage causes aging and why human lifespan may be limited to 115 years. Learn about the 100,000 DNA hits your cells take daily, breakthrough research on the DREAM gene complex that could slow mutation accumulation, and whether we can extend maximum lifespan.In this conversation, Dr. Jan Vijg, Professor and Chair of Genetics at Albert Einstein College of Medicine, explains how genome instability drives the aging process. We explore how your cells sustain 100,000 DNA lesions daily, the difference between DNA damage and somatic mutations, and why mutations accumulate exponentially with age.Dr. Vijg discusses his controversial 2016 Nature paper arguing human maximum lifespan is capped at 115 years, and why mean lifespan improvements don't translate to breaking this limit. He shares exciting new research on the DREAM gene complex - a potential master regulator that could enhance DNA repair across multiple pathways simultaneously.Key topics include: how DNA repair systems decline with age, why long-lived species have better repair mechanisms, tissue-specific mutation rates, the role of SIRT6 and NAD in DNA repair, rare genetic variants in centenarians, and whether pharmacological interventions could slow aging at the cellular level.🌐Links in this video Dr Vijg's page at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/11318/jan-vijgEvidence for a limit to human lifespan https://pubmed.ncbi.nlm.nih.gov/27706136/The DREAM complex links somatic mutation, lifespan, and disease https://www.biorxiv.org/content/10.1101/2025.09.15.676396v1.fullSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Holistic dentist Dr. Namrata Patel reveals how your oral microbiome predicts heart disease, Alzheimer's, and cancer 10-13 years before symptoms appear. Learn about saliva testing, the bacteria that cause systemic inflammation, why tongue exercises reduce sleep apnea 30%, and the daily protocol that protects your healthspan.In this conversation, holistic dentist Dr. Namrata Patel explains how your mouth is an early warning system for chronic disease. We explore the specific bacteria that cause heart attacks, diabetes, cancer, and Alzheimer's - and how saliva testing can detect these risks years before blood tests show problems.Dr. Patel shares breakthrough research on myofunctional therapy, showing how simple tongue exercises can reduce sleep apnea by 30%. We discuss the connection between dry mouth, nitric oxide production, and systemic inflammation, plus why conventional mouthwash may be destroying beneficial bacteria.Key topics include: the optimal daily oral care protocol, how to monitor your oral health at home, the truth about root canals and hidden infections, when to see a functional dentist versus conventional dentist, and why oral health becomes more critical after age 40. Whether you have perfect teeth or chronic health conditions, this episode reveals how your mouth impacts your longevity.🌐Links in this video Green Dentistry Home Page https://sfgreendentist.com/ Dr Patel's book on Amazon:Age With Style: Your Guide To A Youthful Smile & Healthy Living https://amzn.to/49AdQn5Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan