Modern Healthspan

Join us as Dr. Irina Conboy, former UC Berkeley professor and Chief Science Officer at Generation Lab, reveals a groundbreaking metabolic senolytic discovery. Learn how combining Dichloroacetate (DCA), Metformin, and a 10-fold lower dose of Navitoclax selectively eliminates senescent and cancer cells, extending post-treatment lifespan by 41.7% in old mice without inducing frailty or platelet toxicity

Cellular senescence and cancer share a critical metabolic vulnerability: damaged, short-circuiting mitochondria and an inflexible reliance on glycolysis for survival. While first-generation senolytics like Navitoclax (ABT-263) demonstrated high potency, severe clinical side effects like platelet destruction (thrombocytopenia) stalled their translation. In this episode, Dr. Irina Conboy breaks down her lab's landmark 2026 paper in Aging. By utilizing Dichloroacetate (DCA) to force pyruvate into damaged mitochondria and Metformin to inhibit Complex I ATP synthesis, the team created a metabolic vise that drains energy exclusively in cancer and senescent cells. With their defenses compromised, a 10-fold reduced dose of Navitoclax triggers selective apoptosis while completely sparing healthy human tissues and platelets. Dr. Conboy explains how intermittent administration in 18-month-old mice extended post-treatment lifespan by 41.7% (+102 days) and improved treadmill endurance with zero increase in frailty. She also shares Generation Lab's upcoming pharmacological injectable designed to replace invasive therapeutic plasma exchange (TPE).

🔬 Scientific Citations & References Mentioned: 1. Robinson, Z., Amiri, P., Mehdipour, M., Conboy, M. J., & Conboy, I. M. (2026). Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice. Aging, PMID: 42474306. 2. Jeon, O. H., et al., Campisi, J., & Conboy, I. M. (2022). Systemic induction of cellular senescence by old blood. Nature Metabolism, 4(8), 998-1006. 3. Mehdipour, M., et al., & Conboy, I. M. (2020). Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging, 12(10), 8790-8819. 🌐 Links in this video: - Generation Lab: https://generationlab.biotech

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Join us as Dr. Connie Weaver, Distinguished Research Professor at San Diego State University and National Academy of Medicine member, reveals the hidden science of bone loss, calcium bioavailability, and the gut-bone axis. Discover why fractures kill more people than most realize, why modern plant-forward diets are inadvertently blocking mineral absorption, how soluble corn fiber halts postmenopausal bone loss, and the strict 500mg calcium dosing rule you need to know.

Osteoporotic fractures outnumber new diagnoses of heart disease and cancer combined, with 20% of hip fracture patients dying within 12 months. Yet bone health remains one of the most overlooked pillars of healthspan. In this episode, we sit down with Dr. Connie Weaver, one of the world's foremost authorities on mineral metabolism and bone remodeling. Dr. Weaver explains why nutrition plays a permissive role alongside resistance exercise, how the estrogen crash during menopause accelerates osteoclast bone resorption, and why high-dose Vitamin D trials have failed to stop fractures in the general population. She breaks down her landmark 3-decade research modeling calcium bioavailability across global diets (now integrated into Cronometer), revealing how high-oxalate and high-phytate plant diets are driving widespread calcium deficits. Finally, Dr. Weaver shares her groundbreaking discovery on the gut-bone axis - demonstrating how prebiotic soluble corn fiber feeds fiber-fermenting bacteria to stop postmenopausal bone loss - and clarifies the truth about calcium supplements and arterial plaque.

🔬 Scientific Citations & References Mentioned
1. Weaver, C. M., et al. (2016). Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner. The American Journal of Clinical Nutrition, 104(3), 837-843.
2. Weaver, C. M., et al. (2021). Modeling calcium bioavailability in US and global diets: Impact of phytate, oxalate, and plant-forward dietary shifts. The Journal of Nutrition, 151(10), 3120-3128.
3. Whisner, C. M., & Weaver, C. M. (2016). Soluble corn fiber enhances calcium absorption and alters the gut microbiome in adolescent males and females. British Journal of Nutrition, 116(11), 1849-1856.
4. Weaver, C. M., et al. (2016). Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporosis International, 27(1), 367-376.

🌐Links in this video
- Dr. Connie Weaver's SDSU Faculty Page: https://ens.sdsu.edu/people/faculty/weaver-connie - Dr. Connie Weaver on LinkedIn: https://www.linkedin.com/in/connie-weaver-4754a39/ - USDA FoodData Central: https://fdc.nal.usda.gov/ - Cronometer (featuring Dr. Weaver's Bioavailability Model): https://cronometer.com/

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Join us as Dr. Noah Davidsohn, Co-Founder and Chief Scientific Officer of Rejuvenate Bio, reveals how systemic multi-gene therapy and in vivo partial cellular reprogramming can reverse age-related chronic diseases and double remaining lifespan. Discover the breakthrough science of AAV vector delivery, FGF21 and sTGFβR2 synergy, and companion animal clinical translation.

What if a single gene therapy injection could simultaneously treat heart failure, kidney disease, and diabetes? In this episode, we sit down with Dr. Noah Davidsohn, CSO and Co-Founder of Rejuvenate Bio, spun out of George Church’s lab at Harvard Medical School. Dr. Davidsohn breaks down their landmark 2024 study in Cellular Reprogramming, which demonstrated a 109% increase in the remaining lifespan of extremely aged (124-week-old) wild-type mice using systemic AAV9 delivery of Yamanaka factors (OSK). He explains the mechanics of intermittent doxycycline pulsing to avoid tumor risks, the power of multi-gene master regulators like FGF21 and sTGFβR2 in RJB-01, and how treating companion dogs with Mitral Valve Disease serves as the ultimate translational bridge to human clinical trials.

🌐Links in this video
- Rejuvenate Bio Website: https://www.rejuvenatebio.com
- WeFund for Rejuvenate Bio: https://wefunder.com/rejuvenatebio

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In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain’s immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease.
For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this comprehensive masterclass, Dr. Perlmutter reveals why the real driver of brain aging lies within microglia, the brain's resident immune defenders. Under healthy conditions, microglia nurture synapses and clear debris. But when triggered by elevated blood glucose, gut dysbiosis, environmental air toxins, or lack of deep sleep, they flip into an aggressive, destructive phenotype that destroys brain connections. Dr. Perlmutter shares practical, evidence-based protocols to keep your microglia in their protective state: why a fasting glucose above 90 mg/dL poses hidden risks, how muscle-derived myokines cross the blood-brain barrier, the truth about adult hippocampal neurogenesis, and the exact supplement stack (including DHA, Akkermansia, Urolithin A, DHM, and rosmarinic acid) supported by peer-reviewed science.

🌐Links in this video
Dr Perlmutter's book Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life on Amazon https://amzn.to/4y4U77Y Dr Perlmutter's home page https://drperlmutter.com/

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Can AI simulate your exact biology to predict how long you will live? Today we sit down with Dr. Dmitri Chebanov, computational biologist from Memorial Sloan Kettering Cancer Center and Chief Scientist at Holivita, to explore how AI digital twins and multi-omics are turning reactive medicine into proactive longevity.
For decades, health optimization has relied on trial and error: try a new supplement, change your diet, wait three months, and hope your blood work improves. But biology is complex, and standard medical care only reacts after disease develops. Dr. Dmitri Chebanov shares how cutting-edge transformer neural networks, trained on multi-omic patient data, can create a high-dimensional "Digital Twin" of your body. Originally developed to simulate clinical trials in oncology and reduce the 90% trial failure rate, this technology is now transitioning to personal longevity. We break down the three critical layers of a digital twin (whole genome sequencing, dynamic biomarkers like DNA methylation, and real-time symptoms), how to simulate lifestyle interventions before taking a single pill, and what the future of real-time predictive healthcare looks like