Science Savvy

• Food for Thought: How What You Eat Shapes Your Mind, Body, and Relationships

  In this episode of Science Savvy, we dive deep into the fascinating ways food influences our brains, bodies, and even our relationships. Joined by food-loving couple Pablo and Alicia, we explore how the taste, smell, and texture of our meals trigger dopamine release, creating cravings and memories. Discover the science of macronutrients, the gut-brain axis, and how omega-3s can boost brain health. We also discuss how food fosters social bonds and sparks romance, releasing hormones like oxytocin that deepen our connections. Plus, we tackle why highly palatable foods can be so hard to resist, the evolutionary wiring behind our cravings, and the cutting-edge science of the microbiome. Whether you're a health nut, a foodie, or just curious about the science of eating, this episode serves up a banquet of insights. Tune in to get your fill of science-backed "food for thought" and leave with practical tips to feel your best—mind and body. If you enjoyed this episode, don’t forget to subscribe, leave a review on Apple Podcasts or Spotify, and share it with a friend. Follow us on Instagram for more bite-sized science content, and stay savvy! Further reading / references: Omega-3s and cognitive function: Swanson, D., Block, R., & Mousa, S. A. (2012). Omega-3 fatty acids EPA and DHA: Health benefits throughout life. *Advances in Nutrition*, *3*(1), 1-7. https://doi.org/10.3945/an.111.000893. Gut-brain axis: Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. *Annals of Gastroenterology*, *28*(2), 203. Serotonin and the gut: Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., ... & Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. *Cell*, *161*(2), 264-276. https://doi.org/10.1016/j.cell.2015.02.047. Gut microbiome and mental health: Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015). The gut microbiome and diet in psychiatry: Focus on depression. *Current Opinion in Psychiatry*, *28*(1), 1-6. Gut microbiome and autoimmune disorders: Peterson, C. T., Sharma, V., Elmen, L., & Peterson, S. N. (2015). Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. *Clinical and Experimental Immunology*, *179*(3), 363-377. Inflammation and diet: Calder, P. C. (2010). Omega-3 fatty acids and inflammatory processes. *Nutritional Neuroscience*, *13*(3), 183-188. Social bonding and food: Ruddock, H. K., Brunstrom, J. M., Vartanian, L. R., & Higgs, S. (2019). A systematic review and meta-analysis of the social facilitation of eating. *American Journal of Clinical Nutrition*, *110*(4), 842-861. Evolutionary cravings and brain reward systems: Berthoud, H. R., Münzberg, H., & Morrison, C. D. (2017). Blaming the brain for obesity: Integration of hedonic and homeostatic mechanisms. *Gastroenterology*, *152*(7), 1728-1738. https://doi.org/10.1053/j.gastro.2016.12.050. Lab-grown meat: Post, M. J. (2012). Cultured meat from stem cells: Challenges and prospects. *Meat Science*, *92*(3), 297-301. Insect protein and sustainability: van Huis, A., Van Itterbeeck, J., Klunder, H., Mertens, E., Halloran, A., Muir, G., & Vantomme, P. (2013). Edible insects: Future prospects for food and feed security. *FAO Forestry Paper*. FAO: Rome.

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  26:37
• Mind over Migraine: Dehenna Davison on Battling the Invisible Pain

  In this deeply personal episode of Science Savvy, I sit down with Dehenna Davison, former Member of Parliament for Bishop Auckland, who made headlines when she stepped down from her dream job due to chronic migraine. Dehenna is a powerful advocate for migraine awareness, and she shares her journey—from suffering in silence to securing the first UK parliamentary debate on migraine since the 1960s. What you will learn: 💥 The science of migraine: Migraine disease is a debilitating neurological condition that affects over 1 billion people worldwide and is ranked among the top 10 most disabling disorders by the World Health Organization. It's NOT “just a headache”. We'll explain trigeminal nerve activation, neuroinflammation, vasodilation. 💊 Migraine treatments and how they actually work at a molecular level: From triptans and CGRP inhibitors to Botox (botox??) and anticonvulsants (did she say convulsions?) ⚖️ Access to migraine care: The frustrating barriers to treatment and the policy changes we desperately need 💡 The emotional toll of migraine: How it impacts careers, relationships, and mental health 🌍 Migraine advocacy: Why raising awareness is crucial for millions suffering in silence As someone who also lives with migraine, this episode is deeply personal to me. If you or someone you love suffers from migraine attacks, THIS is the episode you need to hear. 🔗 Share this episode to help raise awareness! #MigraineAwareness #ChronicMigraine #Neurology #BrainHealth #InvisibleIllness #DehennaDavidson #SciencePodcast #ScienceSavvy #HealthAdvocacy #HeadacheDisorders #Neuroscience #MigraineTreatment #PodcastForWomen #MentalHealthMatters #HealthPolicy   Bibliography / references / further reading: Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553–622. https://doi.org/10.1152/physrev.00034.2015 Burstein, R., Noseda, R., & Borsook, D. (2015). Migraine: Multiple processes, complex pathophysiology. The Journal of Neuroscience, 35(17), 6619–6629. https://doi.org/10.1523/JNEUROSCI.0373-15.2015 Charles, A. (2018). The pathophysiology of migraine: Implications for clinical management. The Lancet Neurology, 17(2), 174–182. https://doi.org/10.1016/S1474-4422(17)30435-0 World Health Organization (WHO). (2022). Headache disorders: Key facts. Retrieved from https://www.who.int/news-room/fact-sheets/detail/headache-disorders Steiner, T. J., Stovner, L. J., Jensen, R., Uluduz, D., & Katsarava, Z. (2020). Migraine remains second among the world's causes of disability, and first among young women: Findings from GBD2019. The Journal of Headache and Pain, 21(1), 137. https://doi.org/10.1186/s10194-020-01208-0 Buse, D. C., Manack, A. N., Fanning, K. M., Serrano, D., Reed, M. L., & Lipton, R. B. (2012). Chronic migraine prevalence, disability, and sociodemographic factors: Results from the American Migraine Prevalence and Prevention Study. Headache, 52(10), 1456–1470. https://doi.org/10.1111/j.1526-4610.2012.02223.x Lipton, R. B., Bigal, M. E., Diamond, M., Freitag, F., Reed, M. L., & Stewart, W. F. (2007). Migraine prevalence, disease burden, and the need for preventive therapy. Neurology, 68(5), 343–349. https://doi.org/10.1212/01.wnl.0000252808.97649.21 Prince, P. B., Rapoport, A. M., Sheftell, F. D., Tepper, S. J., & Bigal, M. E. (2004). The effect of weather on headache. Headache, 44(6), 596–602. https://doi.org/10.1111/j.1526-4610.2004.446011.x Finocchi, C., & Sivori, G. (2012). Food as trigger and aggravating factor of migraine. Neurological Sciences, 33(S1), 77–80. https://doi.org/10.1007/s10072-012-1046-5 Migraine Treatment: Acute and Preventative Strategies Diener, H. C., Holle, D., Solbach, K., & Gaul, C. (2021). Medication-overuse headache: Risk factors, pathophysiology, and management. Nature Reviews Neurology, 17(2), 112–124. https://doi.org/10.1038/s41582-020-00428-0 Dodick, D. W. (2018). A phase-by-phase review of migraine pathophysiology. Headache, 58(S1), 4–16. https://doi.org/10.1111/head.13300 Silberstein, S. D., Holland, S., Freitag, F., Dodick, D. W., Argoff, C., & Ashman, E. (2012). Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults. Neurology, 78(17), 1337–1345. https://doi.org/10.1212/WNL.0b013e3182535d0c Tepper, S. J., & Ashina, M. (2019). CGRP and migraine: The emerging role of CGRP inhibitors. Headache, 59(3), 394–406. https://doi.org/10.1111/head.13456 Russo, A. F. (2015). Calcitonin gene-related peptide (CGRP): A new target for migraine. Annual Review of Pharmacology and Toxicology, 55, 533–552. https://doi.org/10.1146/annurev-pharmtox-010814-124701 Lipton, R. B., Munjal, S., Alam, A., Buse, D. C., Fanning, K. M., Reed, M. L., & Schwedt, T. J. (2022). The impact of migraine on workplace productivity and the role of novel treatments. Headache, 62(3), 334–345. https://doi.org/10.1111/head.14286

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  42:26
• Lasting habits I think you should build or Neuroplasticity 101

  Your Brain is a Badass. It can literally rewire itself in the face of a challenge! In this episode, we dive into JJ’s inspiring story—a young boy who was born missing key structural elements of his brain but still managed to get better grades than his schoolmates... How? Learn how neuroplasticity (your brain’s ability to adapt) works, and more importantly, how you can use this knowledge to level up your life. Tune in to find out how to make your brain as sharp and flexible as your 2025 goals!   References / Further reading: Zhao, J.-L., Jiang, W.-T., Wang, X., Cai, Z.-D., Liu, Z.-H., & Liu, G.-R. (2020). "Exercise, brain plasticity, and depression." CNS Neuroscience & Therapeutics, 26(9), 885–895.  WILEY ONLINE LIBRARY Damiani, F., Cornuti, S., & Tognini, P. (2023). "The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders." Neuropharmacology, 109491.  PUBMED Rojczyk, A., Dziewanowska, A., & Maryniak, A. (2020). "When the brain looks imperfect: An example of neuroplasticity as seen in a patient with arachnoid cysts—a case study." Frontiers in Neurology, 11, 567. Gulyaeva, N. V. (2017). "Molecular mechanisms of neuroplasticity: An expanding universe." Biochemistry (Moscow), 82(3), 237–242. "Social Networks and Loneliness in People with Alzheimer's Dementia." Balouch S, Rifaat E, Chen HL, Tabet N. Int J Geriatr Psychiatry. 2019 May;34(5):666-673. "Social Networks and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease." Ma YH, Wang YY, Tan L, et al. J Alzheimers Dis. 2021;81(1):263-272. "Social Health, Social Reserve, and Dementia." Sachdev PS. Curr Opin Psychiatry. 2022 Mar;35(2):111-117. "Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs" Journal: J Neurosci. 2021 Mar 31;41(13):2899-2910. "Enriched Environment Increases Neurogenesis and Improves Social Memory Persistence in Socially Isolated Adult Mice" "Adulthood Cognitive Trajectories Over 26 Years and Brain Health at 70 Years of Age" Journal: Neurobiology of Aging (2023) "Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons" Journal: Nat Commun. 2017 Sep 14;8(1):537. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids" Journal: Hippocampus. 2012 Apr;22(4):861-8. "Adult hypothalamic neurogenesis and sleep-wake dysfunction in aging" Journal: Sleep. 2021 Feb 12;44(2):zsaa173. "Sleep and hippocampal neurogenesis: Implications for Alzheimer's disease" Journal: Front Neuroendocrinol. 2017 Apr;45:35-52. "Memory consolidation during sleep and adult hippocampal neurogenesis" Journal: Neural Regen Res. 2019 Jan;14(1):20-23. "Sleep and adult neurogenesis: implications for cognition and mood". Journal: Curr Top Behav Neurosci. 2015;25:151-81.

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  33:39
• Make 2025 your b!tch: Brain hacks to build lasting habits

  Ready to make 2025 your most focused, productive, and fulfilling year? In this episode of Science Savvy, we’re diving into the neuroscience of habit formation, focus, and motivation. Learn five brain-backed strategies to start small, reward yourself, build flexibility, embrace accountability, and pre-decide your goals—all designed to help you stick to your resolutions and create lasting change. Whether you're looking to build healthier routines, master a new skill, or manage your relationship with social media, this episode is packed with actionable insights to help you harness the power of your brain. Tune in and discover how to make this year your best one yet! Bibliography: Wise RA, Jordan CJ. Dopamine, behavior, and addiction. J Biomed Sci. 2021 Dec 2;28(1):83. This study discusses the role of dopamine in habit formation and learning, emphasizing its function in reinforcing behaviors through long-term potentiation (LTP). PMID: 34852810 Lauretani F, et al. Dopamine Pharmacodynamics: New Insights. Int J Mol Sci. 2024 May 13;25(10):5293. - Explores the role of dopamine in neuromodulation and its ability to influence synaptic plasticity, highlighting its relevance in habit formation. PMID: 38791331 Berlucchi G, Buchtel HA. Neuronal plasticity: historical roots and evolution of meaning. Exp Brain Res. 2009 Jan;192(3):307-19. - This article traces the concept of neuroplasticity and its link to learning and habit formation through synaptic changes. PMID: 19002678 Talpos J, Shoaib M. Executive function. Handb Exp Pharmacol. 2015;228:191-213. - Examines the role of the prefrontal cortex in executive function, including goal setting and habit regulation. PMID: 25977083

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  29:48
• All you need is LOVE

  In this episode of Science Savvy, we're diving into the science of love—beyond just romance. From the neuroscience that drives attraction to the biology behind long-term bonding, we explore the fascinating mechanisms behind one of humanity’s most powerful emotions. Together with my friend Alejandra, we break down the stages of love—lust, attraction, and attachment—and discuss the roles of hormones like oxytocin, vasopressin, and dopamine in shaping how we connect with others. We also touch on the physical effects of love and how heartbreak can feel like real, physical pain. Whether you’re curious about why you get butterflies or how love helps us thrive, this episode offers both a deep dive into the science and a personal touch. If you’re interested in learning more, check out the references below for further reading. Further Reading: Helen Fisher’s work on the neuroscience of love Research on oxytocin and vasopressin related to bonding and attachment Studies on dopamine and cortisol in romantic relationships Evolutionary psychology texts on the biological purpose of love Research on the effects of heartbreak on brain activity and emotional regulation References: Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020). What's love got to do with it: Role of oxytocin in trauma, attachment, and resilience. Pharmacology & Therapeutics, 214, 107602. DOI: 10.1016/j.pharmthera.2020.107602 Fisher, H., Aron, A., & Brown, L. L. (2005). Romantic love: An fMRI study of a neural mechanism for mate choice. Journal of Comparative Neurology, 493(1), 58-62. DOI: 10.1002/cne.20772 Stein, D. J., & Vythilingum, B. (2009). Love and attachment: The psychobiology of social bonding. CNS Spectrums, 14(5), 239-242. DOI: 10.1017/s1092852900025384 Acevedo, B. P., Poulin, M. J., Collins, N. L., & Brown, L. L. (2020). After the honeymoon: Neural and genetic correlates of romantic love in newlywed marriages. Frontiers in Psychology, 11, 634. DOI: 10.3389/fpsyg.2020.00634

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  31:13

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