This Week in Virology

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TWiV 1187: The tau of herpesvirus
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease. Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Entry receptor for EV-D68 (Cell Host Microbe) Anti-herpetic tau preserves neurons in Alzheimers (Cell Rep) Letters read on TWiV 1187 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Good genes are nice, but joy is better Brianne – Beaker Hair Clip Kathy – Pareidolia explained by street artist David Zinn TEDx talk Also visit zinnart.com Alan – Screwworm is coming back in the Americas Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation Listener Picks Sarah – The Extremophile Campaign: In Your Home (ECIYH) citizen science Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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1:56:41
TWiV 1186: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tanzania confirms Marburg virus outbreak (Reuters) Clade Ib mpox in England (Reuters) Withdrawing from the World Health Organization (WhiteHouse) Fees costs behind withdrawing from WHO ….is that what we are suppose to believe? (Sky News) Sorry to see you go, US? (WHO) Where are the updates? (CDC Health Alert Network) Pause in health communications of all kind (Washington Post) NIH chaos…..streaming to a halt? (STAT News) Devastation at the NIH, hiring traveling, meetings, communications(Science) Protect your cat from bird flu (NPR) No communication and cats with bird flu….does not sound good (CIDRAP) Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Baloxavir marboxil for prophylatix against influenza(NEJM) Comparative effectiveness of baloxavir marboxil and oseltamir treatment for reducint household transmission of influenza (Influenza and other respiratory viruses) RSV: Waste water scan for 11 pathogens (WastewaterSCan) RSV-Network (CDC Respiratory Syncytial virus Infection) US respiratory virus activity (CDC Respiratory Illnesses) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Host-microbe multiomic profiling identifies distinct COVD-19 immune dysregulation in solid organ transplant recipients (Nature Communications) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19 (Signal Transduction and Targeted Therapy) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long COVID Recovery Program with Zara Dureno, BA, MOT Letters read on TWiV 1186 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
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46:59
TWiV 1185: The birds and the Bs
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 GBS with RSV vaccine (FDA) Increase in respiratory infections in China (ECDC) Elsevier journal editors resign (Retract Watch) Wild bird associated pathogens (Med) Broad anti-neuraminidase antibody (Cell Host Micr) Letters read on TWiV 1185 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Dear Reviewer 2 Rich – National Data Buoy Center Alan – BBC audio program on the World Morse Code Championships Vincent – These are the 20 most-studied bacteria — the majority have been ignored Listener Picks Peter – Local graffiti in Sydney Vivian – The Peoples’ Hospital by Dr. Ricardo Nuila Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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1:51:58
TWiV 1184: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, if “long COVID” like symptoms occurs after influenza and how long COVID may associate with neurological complicates that control verbal memory. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Notable infectious diseases in US (CDC NNDSS) Get your Tdap: whooping cough case increase (California Department of Public Health) Resurgence of measles among preschool aged children 1989-1991 (CDC: MMWR) Adults vulnerable to ‘childhood’ diseases (NY Times) Pivotal decision that led to a resurgence of polio (NY Times) Can polio return due to lagging vaccination? (NY Times) NoroSTAT Data Table (CDC Norovirus) The discovery of the 27-nm Norwalk virus: an historic perspective (JID) Why the “Ferrari of viruses” is surging through the northern hemisphere (Science) Waste water scan for 11 pathogens (WastewaterSCan) Norovirus at Chipotle, $25million food fine (NY Times) Chipotle food issues: 2015 settlement with the justice department (Chipotle News) Purcel anyone? Hand sanitizers increase norovirus risk? (Canadian Medical Association Journal) Visualization by immune electron microscopy of a 27nm particle associated with acute infectious nonbacterial gastroenteritis (Journal of Virology) Winter vomiting disease (JID) ACIP: expanded recommendations for pneumococcal conjugate vaccines(CDC: MMWR) Presumptive bird flu case in San Francisco (SF. Gov) Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) Antiviral medications for treatment ofnonsevere influenza(JAMA Network: JAMA Internal Medicine) Xofluza (GoodRx) RSV: Waste water scan for 11 pathogens (WastewaterSCan) RSV-Network (CDC Respiratory Syncytial virus Infection) US respiratory virus activity (CDC Respiratory Illnesses) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) Symptom evolution in individuals with ongoing symptomatic COVID-19 and post COVID-19 syndrome after SARS-CoV-2 vaccination versus influenza vccination (Journal of Infection) Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory (Scientific Reports) Letters read on TWiV 1184 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
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45:46
TWiV 1183: More than 2024 viruses
TWiV reviews some of their favorite virology stories from 2024. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 SARS-CoV-2 origins (TWiV Special) TWiV 1163: Hepadnaviridae in the heartland TWiV 1117 Pol dances with the RNA that brought it HPV vaccine success (TWiV 1083, 1151, 1159, 1173) Monkeypox (TWiV 1095, 1119, 1143, 1145, 1147) Influenza H5N1 virus (VTWiV 1113, TWiV 1131, TWiV 1173) Influenza B/Yamagata removed from vaccine (TWiV 1161) Fiasco of poliomylelitis eradication (TWiV 1091, TWiV 1125, TWiV 1105, TWiV 1151, TWiV 1145, TWiV 1147, TWiV 1161, TWiV 1143) Protective immunity isn’t just bout antibodies (TWiV 1089, 1105, 1115, 1135, 1165) Closing the toilet lid doesn’t help (TWiV 1083) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Scientists put vampire bats on treadmills to learn about metabolism Kathy – Says Who?: A Kinder, Funner, Usage Guide for Everyone Who Cares About Words Rich – Mark Rober on PBS Newshour Brief But Spectacular (Wiki; Testing The World’s Smartest Crow) Vincent – How Glenn Gould Broke Classical Music Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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1:49:31